Wine for Wheels
Wine for Wheels is a partnership between superfancy California winemakers and the inestimable Wheelchair Foundation. For every $100 bottle of "cult" wine you buy, a wheelchair is donated to one of the 100+ million people with disabilities around the world who wouldn't otherwise have access to a mobility device.
The Wheelchair Foundation has been doing this awesome work for years, but it's this kind of partnership with the consumer-goods-oriented private sector that has real potential to change the world. It's rather like Product RED in that respect: people are going to buy stuff anyway, so why not harness consumerism for good?